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Risks of higher levels of inflammation

hsCRP (high-sensitivity C-Reactive Protein) is an established marker of systemic inflammation.


Higher levels of inflammation may increase risk of heart disease, cancer, and Alzheimer’s disease.


Higher levels of inflammation have been associated with greater symptoms of fatigue, depression, rheumatoid arthritis, migraine, Crohn’s disease, and Irritable Bowel Syndrome.

Category

hsCRP/CRP based risk*

Data to support

Heart disease

hsCRP >0.5mg/L: people with hsCRP >0.5mg/L had an increased risk of cardiovascular disease, as shown in two clinical studies

hsCRP >1mg/L: hsCRP >1mg/L is used in clinical practice as the threshold for increased risk of cardiovascular disease

hsCRP >3mg/L: hsCRP >3mg/L is used in clinical practice as the threshold for “high risk” of cardiovascular disease

Reference 1, 2






Reference 1, 2





Reference 1, 2

Cancer

hsCRP >1mg/L: people with hsCRP >1mg/L had a higher risk of cancer of any type, as shown in multiple clinical studies

Reference 1, 2, 3

Alzheimer’s disease

hsCRP>1.5mg/L: Adults <65 years old with an hsCRP > 1.5 mg/L had an increased risk of developing all cause dementia (dementia, Alzheimer’s disease, and vascular dementia), per a clinical study Note - Higher hsCRP in older adults (e.g., 70.6-94 years old) has been shown to be protective against Alzheimer’s Disease.

Reference 1, 2

Fatigue

hsCRP>1mg/L: People with hsCRP >1mg/L were more likely to develop new onset fatigue, as shown in two clinical studies

Reference 1, 2

Depression

hsCRP >3mg/L: people with hsCRP >3mg/L had greater depression severity, per a summary across multiple studies

Higher hsCRP levels were associated with symptoms of fatigue, restless sleep, low energy, concentration difficulties, poor psychomotor speed, and poor executive functioning


Reference 1

Rheumatoid Arthritis

hsCRP=2-8mg/L: hs-CRP of 2–8 mg/L was predictive of disease activity in Rheumatoid Arthritis, with higher activity relative to hsCRP<2mg/L, per a clinical study

Reference 1

Migraine

hsCRP 10-20mg/L: People with hsCRP between 10-20mg/L had an increased risk of developing chronic migraine (i.e., fulfilled the criteria for migraine and reported headache >or= 15 days/month) compared to those with lower levels, per a clinical study

Reference 1

Crohn’s Disease

CRP>20mg/L: CRP >20mg/L may help predict relapse within 6 weeks, per a clinical study

Note - CRP alone does not typically predict Crohn’s disease relapse.


Reference 1, 2

IBS

Higher hsCRP levels were associated with greater disease severity, per a clinical study

Reference 1

*Be Golden helps you measure your hsCRP. hsCRP and CRP (C Reactive Protein) measure the same molecule (CRP) but hsCRP can measure trace amounts of it.


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