Risks of higher levels of inflammation

hsCRP (high-sensitivity C-Reactive Protein) is an established marker of systemic inflammation.

Higher levels of inflammation may increase risk of heart disease, cancer, and Alzheimer’s disease.

Higher levels of inflammation have been associated with greater symptoms of fatigue, depression, rheumatoid arthritis, migraine, Crohn’s disease, and Irritable Bowel Syndrome.

Category	hsCRP/CRP based risk*	Data to support
Heart disease	hsCRP >0.5mg/L: people with hsCRP >0.5mg/L had an increased risk of cardiovascular disease, as shown in two clinical studies hsCRP >1mg/L: hsCRP >1mg/L is used in clinical practice as the threshold for increased risk of cardiovascular disease hsCRP >3mg/L: hsCRP >3mg/L is used in clinical practice as the threshold for “high risk” of cardiovascular disease	Reference 1, 2 Reference 1, 2 Reference 1, 2
Cancer	hsCRP >1mg/L: people with hsCRP >1mg/L had a higher risk of cancer of any type, as shown in multiple clinical studies	Reference 1, 2, 3
Alzheimer’s disease	hsCRP>1.5mg/L: Adults <65 years old with an hsCRP > 1.5 mg/L had an increased risk of developing all cause dementia (dementia, Alzheimer’s disease, and vascular dementia), per a clinical study Note - Higher hsCRP in older adults (e.g., 70.6-94 years old) has been shown to be protective against Alzheimer’s Disease.	Reference 1, 2
Fatigue	hsCRP>1mg/L: People with hsCRP >1mg/L were more likely to develop new onset fatigue, as shown in two clinical studies	Reference 1, 2
Depression	hsCRP >3mg/L: people with hsCRP >3mg/L had greater depression severity, per a summary across multiple studies Higher hsCRP levels were associated with symptoms of fatigue, restless sleep, low energy, concentration difficulties, poor psychomotor speed, and poor executive functioning	Reference 1
Rheumatoid Arthritis	hsCRP=2-8mg/L: hs-CRP of 2–8 mg/L was predictive of disease activity in Rheumatoid Arthritis, with higher activity relative to hsCRP<2mg/L, per a clinical study	Reference 1
Migraine	hsCRP 10-20mg/L: People with hsCRP between 10-20mg/L had an increased risk of developing chronic migraine (i.e., fulfilled the criteria for migraine and reported headache >or= 15 days/month) compared to those with lower levels, per a clinical study	Reference 1
Crohn’s Disease	CRP>20mg/L: CRP >20mg/L may help predict relapse within 6 weeks, per a clinical study Note - CRP alone does not typically predict Crohn’s disease relapse.	Reference 1, 2
IBS	Higher hsCRP levels were associated with greater disease severity, per a clinical study	Reference 1

*Be Golden helps you measure your hsCRP. hsCRP and CRP (C Reactive Protein) measure the same molecule (CRP) but hsCRP can measure trace amounts of it.

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